What are the specs of your machine?
What software are you trying to open?
What anti spyware software are you using?

We kinda need to know at least the answers to these questions to even begin to help.

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Rig Specs: Custom Built:
ASUS M2N4-SLI
AMD Athlon 64 X2 Dual 4600+
512MB SLI NVIDIA GeForce 7950GT OC
2.00 GB Elixiur RAM
400GB Hitachi SATA II HDD
Western Digital 120GB IDE HDD
Samsung SyncMaster 932B Monitor
More to follow soon.....