Help!!!!!!

I am trying to get into control panel....etc but everything i try to open wont work.....I click on it and all the icons dissapear then come back...I have rebooted several times and in safe mode...and nothing has happened...I have restored it also to an earlier time and this has fixed it for a while then its back again...I have all the latest anti virus and spyware removals...I have also downloaded the sysinternals....but I dont know what to do next....Can anyone HELP ME?????