Cluster size?

Well now that I got a new hard drive, I was thinking about partitioning and selecting cluster size for each partition.

After reading a while, I decided that the "system" partition, where Windows, OpenOffice, programs and stuff will have the default cluster size, while my other partition where I have all my music will have the biggest cluster size. Though I sacrifice a little space, seems that this is better. It's yet hard to benchmark it to see if there is any difference.

Do you guys have any experience with this?