RegScrub XP is definately my registry cleaner of choice. However, I also use CCleaner, sometimes. Whenever I clean up all the junk (I seem to have a lot of beta applicaions) in my system I always use CC an Disk clean up... since a lot of applications are in my start up list after I delete them, I need to clean up my registry, so I think using registry cleaners might be good for your comp.