Three tips that I have found in repairing this issue.

1)Turn off AERO and see if that helps.

2)If not look for a bad shortcut file on your desktop.....create a new folder and drag and drop all the desktop icons into the folder. open the folder and try to use each icon seperately....the bad one should close down the program...just delete the bad one and create a new one and you should be set to go.

3 this one takes a regestry edit

Open the run application and type the following

regsvr32 /u lmpgspl.ax and hit enter

After it is done change the file to lmpgspl.ax.old

lmpgspl.ax is a file from from Ligos Corporation the command unregisters this file. The file is part of a codec and is not truely Vista ready and has been known to dreate these type of issues

Hope this helps